Price range: $129.00 through $450.00
Pentosan polysulfate is a semi-synthetic polysulfated xylan used for the relief of Osteoarthritis. It can provide stimulation of cartilage matrix synthesis and prevention of cartilage breakdown. There are also systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation.
Pentosan polysulfate is a semi-synthetic polysulfated xylan used for the relief of Osteoarthritis. The mechanism of PPS action in osteoarthritis is stimulation of cartilage matrix synthesis and prevention of cartilage breakdown. There are also systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation. This is a subcutaneous injection self-administered twice a week for 6 weeks. Most patients have relief from symptoms within 1-2 weeks and may achieve full remission of symptoms in 2-6 months. The nasal spray is used once your symptoms have been in remission to prevent a relapse of inflammation and pain.
Formulation
Pentosan Polysulfate (PPS) is an injectable therapy that can be used to help reduce joint pain and inflammation in osteoarthritis.
It can aid in protecting cartilage, improving joint function, and decreasing pain by reducing inflammation and improving blood flow in affected joints.
Adults with osteoarthritis who want a non-opioid, non-steroidal option for managing joint pain.
Yes, as long as you’re not taking blood thinners or have contraindications determined by your provider.
Administered as a subcutaneous injection, typically 2 times weekly x 6 weeks, under the direction of a provider.
Follow your personalized schedule; typically, injections are spaced evenly through the week.
Doses are customized based on your weight and severity of osteoarthritis.
Some patients notice improvement within 4–6 weeks, with continued progress over 8–12 weeks.
Pentosan polysulfate is prescribed as a 6 week course. Some patients notice full pain relief after 1 round. Other patients need 1-2 repeat rounds. It is often given as 3 courses per calendar year.
Yes, under medical supervision. It should not be taken if you are using blood thinners due to increased bleeding risk.
Mild bruising at injection sites or temporary gastrointestinal discomfort are possible.
Yes. A prescription from a licensed provider is required.
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PPS can help to reduce joint inflammation, protect cartilage, and improve blood flow to enhance joint repair and reduce pain.
Yes. Clinical studies show PPS can help improve pain and function in osteoarthritis patients.
Basic labs and a review of your medications are recommended to ensure safe use.
Yes. PPS can complement weight management, physical therapy, and anti-inflammatory diets.
Compounded medications are prepared by a state-licensed pharmacy for individual patients and have not been reviewed or approved by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality. If FDA-approved medications in this class are available; your provider will discuss all options and determine what is appropriate for you. Individual results vary. All medication use requires medical supervision and ongoing lifestyle support.
Book a consultation with Mobile Care Health to see if PPS therapy is right for your joints.
| Formulation | Nasal Spray, 5ml Vial for Injection, 2 – 5ml Vials for Injection, Capsules |
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