Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, also referred to as an incretin mimetic. GLP-1 agonists were initially developed to improve glycemic control with type 2 diabetics as an adjunct to diet and exercise. It works to enhance the growth of beta cells in the pancreas, delay gastric emptying by reducing glucagon secretion in a glucose-dependent manner. The delay in gastric emptying can reduce appetite, improve control of eating, and reduce food cravings. You may have seen this recent article, NJEM STEP article that was published this year. Patients lost an average of 33lbs over the course of the trial period. This was a major step forward in weight loss medicine.

Getting Started

If you are ready to get started on Semaglutide, let us know as soon as possible! This is currently on backorder due to the demand. Right now this is offered in a 5mg/2ml vial for $379. This is dosed once a week as a subcutaneous injection. Subcutaneous injections can be given straight in at a 90 degree angle or at a 45 degree angle. Give the injection at a 90 degree angle if you can grasp 2 inches of skin between your thumb and first finger. If you can grasp only 1 inch of skin, give the injection at a 45 degree angle.

• Open the alcohol wipe: Wipe the area where you plan to give the injection. Let the area dry. Do not touch this area until you give the injection.
• Prepare the needle: Hold the syringe with your writing hand and pull the cover off with your other hand. Place the syringe between your thumb and first finger. Let the barrel of the syringe rest on your second finger.
• Grasp the skin: With your other hand, grasp the skin.
• Insert the needle into the skin: Hold the syringe barrel tightly and use your wrist to inject the needle into the skin. Once the needle is all the way in, push the plunger down to inject the medicine.
• Pull out the needle: Remove the needle at the same angle you put it in. Gently wipe the area with the gauze pad.